真核生物のリボソームRNA遺伝子―5SRNA遺伝子の構造と機能―
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概要
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This review has summarized the recent knowledge about structure and expression of the 5S RNA genes in eucalyotes.<BR>5S RNA is an integral component of the large subunit of the ribosome. Eucaryotic cells contain per haploid 1010<SUP>2</SUP>-10<SUP>4</SUP> copies of the gene for this small RNA. Three different types of genomic organization of the 5S RNA genes have been observed by gene cloning and hybridization experiments. Primary structure of the various 5S RNA genes and their adjacent regions has been determined, which pnovides lots of clues to understand function and evolution of the gene.<BR>In parallel with the structural analyses, mechanisms of 5S RNA transcription and its regulation have been studied by using in vitro transcription systems, The central region of the 5S RNA gene directs the accurate and effective initiation of transcription. Besides RNA polymerase III, at least two protein factors concern the initiation process, and one of these proteins named "TFIIIA" binds specifically to the central region of the gene.
- 日本生物物理学会の論文