1980-2009年の30年間における新有効成分含有医薬品—その標的分子及び生化学的特徴の変化—
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概要
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We analyzed the therapeutic target molecules and biochemical properties of 893 new drugs with new molecular entities approved over three decades from 1980 to 2009 in Japan. According to our analysis of the therapeutic targets, 26.2% of new drugs were enzymes. Membrane receptors were found to be the second-most frequent molecular targets of the new drugs, representing 25.3% of the new drugs approved. The biochemical properties of the drugs were found to have changed over time. Though the total number of new drugs approved from the year 2000 was smaller than that in the 1980s and 1990s, the number of new protein drugs approved in the 2000s, largely recombinant bioactive substances and monoclonal antibodies, increased significantly compared with those approved in the 1980s and 1990s. The results obtained in this study indicated changes in the therapeutic targets, biochemical properties and therapeutic areas of new drugs approved over the last 30 years and suggest the aspects of the future development of new drugs.
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関連論文
- 1980-2009年の30年間における新有効成分含有医薬品—その標的分子及び生化学的特徴の変化—
- 1980-2009年の30年間における新有効成分含有医薬品(NAIs)—標的酵素の反応特性と NAIs 創出の推移—