Effects of Acute Hepatic and Renal Failure on Pharmacokinetics of Flunixin Meglumine in Rats

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概要

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• The aim of this study was to investigate the effects of hepatic and renal failure on the pharmacokinetics of flunixin in carbon tetrachloride (CCl4)- and glycerol-treated rats. After intravenous administration of flunixin (2 mg/kg), the plasma concentration of flunixin was measured by high-performance liquid chromatography. Both acute hepatic and renal failure resulted in significantly increased area under the curve (AUC), prolonged elimination half-life (t1/2β), and reduced total body clearance (Cltot) compared with respective controls (P<0.05). In conclusion, hepatic failure as well as renal failure modified the pharmacokinetics of flunixin.

著者

• Hwang Youn-Hwan

  Institute of Veterinary Science, Lab of Veterinary Pharmacology and Toxicology, College of Veterinar

• YUN Hyo-In

  Institute of Veterinary Science, Lab of Veterinary Pharmacology and Toxicology, College of Veterinar

関連論文

• Pharmacokinetics of Toltrazuril and Its Metabolites, Toltrazuril Sulfoxide and Toltrazuril Sulfone, after a Single Oral Administration to Pigs
• Effects of Acute Hepatic and Renal Failure on Pharmacokinetics of Flunixin Meglumine in Rats
• Effects of Acute Hepatic and Renal Failure on Pharmacokinetics of Flunixin Meglumine in Rats

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