Dendritic Cells Targeting Flt3 Ligand As Molecular Mucosal Adjuvant
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概要
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Nasal antigen plus mucosal adjuvant delivery has emerged as perhaps the most effective route for induction of both mucosal and peripheral immune response. It has been shown that dendritic cells (DCs) played essential roles for the induction of both immunity and tolerance. Thus, nasal application of CpG ODN targeting plasmacytoid DCs effectively induced antigen-specific immunity. Our recent studies showed that nasal or oral immunization with protein antigen, ovalbumin plus plasmid encoding Flt3 ligand (pFL) cDNA as adjuvant effectively elicited OVA-specific immune responses in both mucosal and systemic lymphoid tissues. The numbers of (DCs) in mice given pFL as mucosal adjuvant were significantly increased. Further, these expanded DCs were activated and expressed MHC II and co-stimulatory molecules (CD40, CD80 and CD86). These results show that mucosal delivery of pFL is DCs targeting adjuvant system that effectively induce both mucosal and systemic antigen-specific immune responses.
著者
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Fujihashi Keiko
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Kataoka Kosuke
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Suzuki Hideaki
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Sims Rebekah
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Sekine Shinichi
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Kobayashi Ryoki
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Fukuiwa Tatsuya
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Mizuno Takanari
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Jackson Raymond
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Boyaka Prosper
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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McGhee Jerry
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham
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Fujihashi Kohtaro
The Immunobiology Vaccine Center, Departments of Pediatrics Dentistry and Microbiology, The University of Alabama at Birmingham