Two Novel Alkaloids from the Stem of Saprosma hainanense and Their Cytotoxic Activities in Vitro
スポンサーリンク
概要
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Two novel alkaloids, saprosmine A (1) and saprosmine B (2), were isolated from the stem of Saprosma hainanense MERR., along with five known alkaloids: marcanine A (3); cleistopholine (4); 4-methoxycarbonyl-5,10-benzogquinolinequinone (5); liriodenine (6); and quinoline (7). The chemical structures were established on the basis of extensive spectroscopic (IR, 1D-NMR, 2D-NMR, MS) data analysies and by comparison with spectroscopic data reported in the literature. Compounds 1 to 6 were evaluated for in vitro cytotoxic activities against the SPC-A-1 (human lung cancer), BEL-7402 (human hepatocellular carcinoma), SGC-7901 (human gastric cancer), and K-562 (human myelogenous leukaemia) cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxic activities against K-562 cells. Compounds 3 and 5 showed cytotoxic activities against all four cancer cell lines.
著者
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HUANG Xin
Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University
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Wang Lin
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Chen Guang-Ying
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Han Chang-Ri
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Yuan Yuan
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Yang Biao
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Zhang Yuan
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Wang Jing
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Zhong Xiu-Qiong
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry
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Huang Xin
Key Laboratory For Supramolecular Structure And Materials Of Ministry Of Education Jilin University
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Zhang Yuan
Key Laboratory Of Biogeography And Bioresource In Arid Land Xinjiang Institute Of Ecology And Geography Chinese Academy Of Sciences
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Han Chang-Ri
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Zhong Xiu-Qiong
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Huang Xin
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Wang Lin
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Chen Guang-Ying
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Zhang Yuan
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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Yang Biao
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University
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- Two Novel Alkaloids from the Stem of Saprosma hainanense and Their Cytotoxic Activities in Vitro
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