Pd0-Mediated Rapid C-[11C]Methylations and C-[18F]Fluoromethylations: Revolutionary New Methodologies for the Synthesis of Short-Lived PET Molecular Probes
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概要
- 論文の詳細を見る
A revolutionary new methodology for introducing a short-lived radionuclide 11C into carbon frameworks of biologically significant organic compounds has been established by developing rapid C-[11C]methylations and C-[18F]fluoromethylations using Pd0-mediated cross-coupling reactions between [11C]methyl iodide or [18F]fluoromethyl iodide (or bromide) and excess amounts of organostannane or organoboron compounds. These rapid reactions provide firm chemical bases for an efficient, general synthesis of short-lived 11C- and 18F-labeled PET molecular probes in order to strongly promote in vivo molecular science.
- 社団法人 有機合成化学協会の論文
著者
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Suzuki Masaaki
RIKEN Center for Molecular Imaging Science (CMIS)
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Doi Hisashi
RIKEN Center for Molecular Imaging Science (CMIS)
関連論文
- Pd0-Mediated Rapid C-[11C]Methylations and C-[18F]Fluoromethylations: Revolutionary New Methodologies for the Synthesis of Short-Lived PET Molecular Probes
- Pd^0-Mediated Rapid C-[^C]Methylations and C-[^F]Fluoromethylations : Revolutionary New Methodologies for the Synthesis of Short-Lived PET Molecular Probes
- Pd^0-Mediated Rapid C-[^F]Fluoromethylation by the Cross-Coupling Reaction of a [^F]Fluoromethyl Halide with an Arylboronic Acid Ester : Novel Method for the Synthesis of a ^F-Labeled Molecular Probe for Positron Emission Tomography