Spectroscopic Susceptibility Measurements of Magnetic Markers by SV-GMR Needle Probe

概要

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The needle type probe consists of four spin valve giant magnetoresistive (SV-GMR) elements connected in a Wheatstone bridge. SV-GMR sensing element has dimmensions 40 μm per 75 μm. Needle probe has sensitivity equal to 11μV/μT. Extremely small size and specific construction of this type probe make it possible to detect the changes of susceptibility directly from the sample. The aim is to present the methodology for spectroscopy measurements by SV-GMR needle probe. This article introduces setup feasible to perform spectroscopic magnetic markers measurement. It includes preliminary data connected with signal changes caused by magnetic markers dilution. It shows influence of particle size changes (120 nm, 3.5 μm, 6.5 μm) on real and imaginary part of complex susceptibility. While performing measurements probe sensing elements were placed inside the sample. The intension of this work is to address the methodology for spectroscopy measurement which can be applied in liquid phase immunoassay in the future.