Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice

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概要

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• This study aims to understand Th2 immune responses and alternative macrophage activation against nematode parasites in aged mice. Eighteen-month (18 M) and three-month (3 M) old C3H/HeN mice were inoculated with Heligmosomoides polygyrus (Hp) larvae. Real-time PCR analysis indicated that interleukin (IL)-4 and IL-13 gene expression was elevated in both groups after infection, but the expression level was significantly low in 18 M mice. Macrophage phenotype was monitored by measuring arginase-1 gene expression and immunofluorescence staining in small intestine, showing a decrease in the number of alternatively activated macrophages (AAMacs) around worm cysts in 18 M mice. These results suggest that the Th2 immune response in aged mice against a nematode parasite was not sufficiently induced to promote AAMacs.

著者

• SUGAWARA Yasuhiro

  School of Food, Agricultural and Environmental Sciences, Miyagi University

• AZUMA Noritsugu

  School of Food, Agricultural and Environmental Sciences, Miyagi University

• ONODERA Sachi

  School of Food, Agricultural and Environmental Sciences, Miyagi University

• TSUNOKA Yuichi

  School of Food, Agricultural and Environmental Sciences, Miyagi University

• MORIMOTO Motoko

  School of Food, Agricultural and Environmental Sciences, Miyagi University

関連論文

• Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice
• Orally Administrated Rutin Inhibits the Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice

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