Detection of Annexins I and IV in Bronchoalveolar Lavage Fluids from Calves Inoculated with Bovine Herpes Virus-1.

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概要

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• Annexins are phospholipid-binding proteins and are abundant in the lung. Annexins I and IV, but not II and VI, have been detected in broncholaveolar lavage (BAL) fluids from calves inoculated with Pasteurella haemolytica, the pathogen for calf pneumonia. In this study, BAL fluids from calves with experimental pneumonia induced by inoculation to right lung lobes of bovine herpes virus-1 (BHV-1), the major viral pathogen for pneumonia, were examined for detection of annexins I and IV. Of 6 calves inoculated with BHV-1, annexins I and IV were coincidentally detected in BAL fluids from right lung lobes of 4 calves, but not in BAL fluids from left lung lobes of 6 inoculated calves or those from left and right lung lobes of 3 control calves. Annexin II and VI were not found in any BAL fluids examined. These results, together with previous findings on calves inoculated with Pasteurella haemolytica, suggest that the release of annexins I and IV onto the alveolar surface is an essential event occurring in response to pulmonary infections of BHV-1 and Pasteurella haemolytica.

著者

• KATOH Norio

  The Department of Systematic Diagnosis, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305-0856, Japan

関連論文

• Detection of Annexins I and IV in Bronchoalveolar Lavage Fluids from Calves Inoculated with Bovine Herpes Virus-1.
• Decreased Apolipoprotein C-III Concentration in the High-Density Lipoprotein Fraction from Calves Inoculated with Pasteurella haemolytica and Bovine Herpes Virus-1.

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