Development of Novel Cosmetic Base Using Sterol Surfactant. II. Solubilizing of Sparingly Soluble Ultraviolet Ray Absorbers†

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概要

• 論文の詳細を見る

• Previous studies have reported that O/W emulsion prepared using a surfactant with phytosterol as the hydrophobic moiety exhibited unique morphology; a lamellar structure was present on the surface of the emulsified particles. It is suggested that such a unique self-organized structure was due to the large and bulky planar structure of the sterol. On the other hand, sparingly soluble compounds including ultraviolet ray absorbers and medicines (e.g., indomethacine and finasteride) have been used after they are dissolved mainly in polar oils. However, it is very difficult to dissolve them in bases that contain small amounts of oil components such as lotions. Moreover, many of these sparingly soluble compounds have planar structures such as aromatic rings and are easy to crystallize in polar oil. In this study, sterol surfactants were considered suitable for solubilizing sparingly soluble compounds, since they have a bulky planar structure in their molecules. On this basis, the solubilization of ultraviolet ray absorbers using sterol surfactants was investigated. Methods to solubilize ultraviolet ray absorbers stably and effectively by using a surfactant that had a phytosterol structure have been clarified. Further, the following features were also suggested: (1) the microemulsion of phytosterol surfactant is different from that of other surfactants and (2) a rigid core that has solubilized compounds between the hydrophobic moieties was considered; further, the core was surrounded by a polyoxyethylene chain that prevented the self-aggregation. Analysis using NMR measurements suggested that (1) the polyoxyethylene/polyoxypropylene random copolymer dimethyl ether squeezed in a narrow gap between the hydrophobic moieties of the surfactant, and (2) this eventually increased the solubilized amount of an ultraviolet ray absorber.

• 日本油化学会の論文

著者

• Miyahara Reiji

  Shiseido Research Center

• Oka Takashi

  Shiseido Res. Center (shinyokohama)

• Teshigawara Takashi

  Shiseido Research Center

• Miyahara Reiji

  Shiseido Basic Research Center

• Fukuhara Tadao

  Shiseido Research Center (Shinyokohama)

• Oka Takashi

  Shiseido Research Center (Shinyokohama)

• Teshigawara Takashi

  Shiseido Research Center (Shinyokohama)

関連論文

• A Narrow Bicontinuous Microemulsion Domain in Mixed Polymeric Silicone Systems
• Development of Novel Cosmetic Base Using Sterol Surfactant. I. Preparation of Novel Emulsified Particles with Sterol Surfactant+
• Properties of Fatty Acid Soap with Sodium N-Methyltaurine as Counter-ion. II. N-Methyltaurine for Detergent Application
• Properties of Fatty Acid Soap that Counter-ion is Sodium N-Methyltaurine〔和文〕
• Development of Novel Multifunctional Cosmetic Raw Materials and Their Applications. II.† Novel Emulsifying Method with Random Copolymer of Polyoxyethylene / Polyoxypropylene
• Development of Novel Multifunctional Cosmetic Raw Materials and Their Applications. III.† Effect of Random Copolymer of Polyoxyethylene/polyoxypropylene on Self-organizing Structures of Nonionic Surfactants
• Development of Novel Multifunctional Cosmetic Raw Materials and Their Applications. IV. The Effect of Structure of Polyoxyethylene / Polyoxypropylene Derivative on the Self-organizing Structures of Surfactants
• Development of Novel Cosmetic Base Using Sterol Surfactant. II. Solubilizing of Sparingly Soluble Ultraviolet Ray Absorbers†
• Development of Novel Multifunctional Cosmetic Raw Materials and Their Applications. I. Characterization of a Random Copolymer of Polyoxyethylene / Polyoxypropylene Dimethyl Ether†

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