Association of the Suckling-Weaning Transition with Development of the Hypothalamic Arcuate Nucleus Neurons in Rat Pups

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概要

• 論文の詳細を見る

• Feeding behavior is regulated by feeding-related peptides in the hypothalamus. The neurons of the arcuate nucleus (ARC), which produces feeding-related peptides, develop and function by three weeks of age in rodents. Because rodents are weaned at three weeks, we studied whether the process of weaning is involved in the development of ARC neurons using monosodium glutamate. Rat pups injected neonatally with monosodium glutamate ingested a large amount of mother's milk at weaning. Monosodium glutamate treatment induced a decrease in the number of ARC cells and mRNA levels of neuropeptide Y and agouti-related protein in the hypothalamus. The alteration of milk consumption following monosodium glutamate treatment appears to cause failure of ARC neuron development and neuropeptide expression.

• Japanese Association for Laboratory Animal Scienceの論文

著者

• Minai Yuji

  Department Of Applied Biological Chemistry Faculty Of Agriculture Tamagawa University

• Haga Minoru

  Department of Agricultural Chemistry, Faculty of Agriculture, Tamagawa University

• MINAI Yuji

  Departments of Life Science, College of Agriculture, Tamagawa University

• MIYATA Tohru

  Departments of Bioresource Science, College of Agriculture, Tamagawa University

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• Association of the Suckling-Weaning Transition with Development of the Hypothalamic Arcuate Nucleus Neurons in Rat Pups
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