The Effects of Interleukin-6 and Cytokine-Induced Neutrophil Chemoattractant-1 on α2-Macroglobulin Production in Rats

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概要

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• We investigated the effects of interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) on α2-macroglobulin (α2M) production in rats. IL-6-rich and CINC-1-rich fractions were separated from serum obtained from rats 12 h after injection with turpentine oil using gel-chromatography. Sexual dimorphism was observed in the peak levels of α2M after injection of IL-6-, CINC-1-, or a mixture of IL-6-and-CINC-1-rich fractions. No significant differences in α2M levels were observed in males after injection with IL-6- or CINC-1-rich fractions and those injected with normal serum obtained from healthy rats (control). In contrast, serum levels of α2M, 6 to 120 h after injection of a mixture of IL-6- and CINC-1-rich fractions were significantly higher than in control rats. These results suggest that IL-6 and CINC-1 contribute to α2M production in rats only when IL-6 and CINC-1 act synergistically.

著者

• 栗林 尚志

  麻布大学 環境保健

• KURIBAYASHI Takashi

  Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University

• SEITA Tetsurou

  Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University

• YAMAMOTO Shizuo

  Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University

• Yamamoto Shizuo

  Laboratory Of Immunology College Of Environmental And Health Sciences Azabu University

• HONJO Toshio

  Seminar on Environment, School of Life and Environmental Science, Azabu University

• MOKONUMA Yui

  Laboratory of Immunology, School of Life and Environmental Science, Azabu University

• YAMAGA Ayaka

  Laboratory of Immunology, School of Life and Environmental Science, Azabu University

• YAMAZAKI Shunsuke

  Laboratory of Physiology, Department of Food and Nutrition, Kamakura Women’s University

• Yamamoto Shizuo

  Laboratory Of Immunology Azabu University

• Kuribayashi Takashi

  Laboratory Of Immunology College Of Environmental And Health Sciences Azabu University

• YAMAMOTO Shizuo

  Laboratory of Immunology, School of Life and Environmental Science, Azabu University

• 本庄 利男

  Seminar on Environment, School of Life and Environmental Science, Azabu University

• 栗林 尚志

  Laboratory of Immunology, School of Life and Environmental Science, Azabu University

• 清田 哲郎

  Laboratory of Immunology, School of Life and Environmental Science, Azabu University

• YAMAZAKI Shunsuke

  Laboratory of Physiology, Department of Food and Nutrition, Kamakura Women's University

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