Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome

スポンサーリンク

概要

• 論文の詳細を見る

• Objective Left ventricular systolic time intervals, including pre-ejection period (PEP), ejection time (ET), and their ratio (PEP/ET), is determined by systolic and diastolic function and ventriculo-arterial coupling. We investigated the usefulness of the electromechanical activation time [(EMAT) PEP minus isovolumic contraction time] in the prediction of cardiac mortality or re-hospitalization for heart failure in patients with the acute heart failure syndrome (AHFS). Patients and Methods A total of 45 patients (71.9±16.1 years old) hospitalized for AHFS were enrolled. Systolic time intervals and EMAT normalized by cardiac cycle length (%) were measured separately by separate automated acoustic devices. All parameters were assessed within 24 hours of admission, before discharge, and 2 weeks after discharge. Results During a mean follow-up of 242±156 days, 20 patients (44%) incurred adverse cardiovascular events including 18 re-hospitalizations for heart failure and 2 cardiovascular deaths. Using uni-variate Cox regression analysis, at admission %EMAT and %PEP, pre-discharge %EMAT, and post-discharge %EMAT significantly predicted post-discharge cardiovascular events with hazard ratios and 95% confidence intervals of 1.75 (1.13-2.70), 1.67 (1.02-2.70), 1.87 (1.10-3.17) and 2.50 (1.58-3.97) per 1-SD increment, respectively. The predictions remained significant after adjustment for age, sex, left ventricular ejection fraction, E/E´ by Doppler echocardiography, and serum N-terminal pro-brain natriuretic peptide. Conclusion EMAT measured during the hospitalization course is useful in the prediction of cardiovascular outcomes in patients with AHFS independent of left ventricular ejection fraction, E/E´, and serum N-terminal pro-brain natriuretic peptide.

著者

• CHEN Chen-Huan

  Department of Medical Research and Education, Taipei Veterans General Hospital

• Yu Wen-chung

  Department Of Medicine National Yang-ming University

• Cheng Hao-min

  Department Of Medical Research And Education Taipei Veterans General Hospital

• Wang Kang-ling

  Department Of Medicine National Yang-ming University

• Chen Chen-huan

  Department Of Internal Medicine Taipei Veterans General Hospital

• Sung Shih-hsien

  Department Of Internal Medicine Taipei Veterans General Hospital

• Wang Kang-Ling

  Department of Medicine, Taipei Veterans General Hospital

• Chao Tze-Fan

  Department of Medicine, Taipei Veterans General Hospital

• Huang Chi-Ming

  Department of Medicine, Taipei Veterans General Hospital

関連論文

• Estimation of central systolic blood pressure using an oscillometric blood pressure monitor
• Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome
• Adiponectin, but Not Leptin or High-Sensitivity C-Reactive Protein, Is Associated with Blood Pressure Independently of General and Abdominal Adiposity

スポンサーリンク