Progressive Multifocal Leukoencephalopathy in Myelodysplastic Syndrome Involving Pure Red Cell Aplasia

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概要

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• Progressive multifocal leukoencephalopathy (PML) is a rare and fatal demyelinating disease of the central nervous system caused by JC polyomavirus (JCV) reactivation in an immunocompromized host. We describe a case of PML in a 76-year-old woman with myelodysplastic syndrome, who had been treated with azathioprine for a pure red cell aplasia-like condition. PML was diagnosed based on the neurologic symptoms, the magnetic resonance imaging patterns and the detection of JCV DNA in the cerebrospinal fluid. She died ten months after the diagnosis. An autopsy confirmed the diagnosis, and JCV DNA was detected in the cerebrum. Azathioprine might have triggered PML.

• 一般社団法人 日本内科学会の論文

著者

• SHIRASE Tomoyuki

  Department of Pathology, Ohtsu Red Cross Hospital

関連論文

• Progressive Multifocal Leukoencephalopathy in Myelodysplastic Syndrome Involving Pure Red Cell Aplasia

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