The Potential of Somatic Stem Cells for Alveolar Bone Tissue Engineering

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概要

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• Dental implants cannot be installed without sufficient bone and patients lacking adequate bone volume may have a poor prognosis for implantation. Furthermore, there is increasing demand for esthetic restoration in dental implants. Accordingly, bone regeneration is required in many cases, not only for successful dental implant installation but also for esthetic and prosthetic reasons. However, bone regeneration is not an easy procedure to perform. Autologous bone grafts require a healthy donor site, and bone collection may cause donor site morbidity. Artificial bone substitutes can be used for relatively smaller defects. However, the application is limited and artificial materials are not generally accepted as a complete replacement for an autologous bone graft. Accordingly, less invasive and more efficient methods for bone regeneration are required. Tissue engineering is a new discipline for the restoration of lost or damaged tissue. In most cases, cultured cells, biodegradable scaffold materials and/or bioactive molecules have been used to aid naturally existing regenerating ability. The potential of bone tissue engineering has been actively explored since the discovery of osteogenic cells in bone marrow. In terms of alveolar bone tissue engineering, both basic research and clinical studies have been published recently. While clinical studies seem promising, they also highlight some problems, such as the unstable nature of somatic stem/progenitor cells and individual variation. Current studies are being performed to overcome those shortcomings, aiming to establish it as a novel treatment option in the near future.

著者

• Kagami Hideaki

  Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo

• Agata Hideki

  Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo

関連論文

• Efficacy of Membranous Cultured Periosteum for the Treatment of Patients with Severe Periodontitis: a Proof-of-Concept Study
• Decellularized ureter for tissue-engineered small-caliber vascular graft
• THE INDUCTION OF DENTIN BRIDGE-LIKE STRUCTURES BY CONSTRUCTS OF SUBCULTURED DENTAL PULP-DERIVED CELLS AND POROUS HA/TCP IN PORCINE TEETH
• Differential Inducibility of Human and Porcine Dental Pulp-Derived Cells into Odontoblasts
• The Potential of Somatic Stem Cells for Alveolar Bone Tissue Engineering

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