Preparation of Protein Transduction Domain-Fused Peptidyl Prolyl cis/trans Isomerase Pin1

スポンサーリンク

概要

• 論文の詳細を見る

• The phenotypes of mice lacking peptidyl prolyl cis/trans isomerase Pin1 (Pin1−⁄−) indicated that deficient Pin1 might be related to a variety of diseases. We created TAT-Pin1, a fusion protein of human immunodeficiency virus 1 trans-activator of transcription factor with Pin1. Treatment of HeLa cells with TAT-Pin1 increased the ratio of the S phase. Moreover, TAT-Pin1 restored the proliferating function of Pin1−⁄− mouse embryonic fibroblasts which cannot restart proliferation after G0 arrest. These results indicate that TAT-Pin1 is useful in studying the functions of Pin1 and can be developed as a macromolecular drug for diseases related to Pin1 loss.

• 社団法人 日本農芸化学会の論文

著者

• UCHIDA Takafumi

  Molecular Enzymology, Molecular Cellular Biology, Agricultural Science, Tohoku University

• OHASHI Tsubasa

  Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science,

• TESHIMA Sumito

  Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science,

• HIDAKA Masafumi

  Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science,

関連論文

• Novel Functions of Prolyl Isomerase Pin1(Recent Topics of the Agricultunal Biological Science in Tohoku University)
• Preparation of Protein Transduction Domain-Fused Peptidyl Prolyl cis/trans Isomerase Pin1

スポンサーリンク