Lobophytones H—N, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum

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概要

• 論文の詳細を見る

• Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids, named lobophytones H—N (1—7). Their structures were determined by interpretation of 1D- and 2D-NMR (correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)) spectroscopic data in association with MS and IR data. All compounds were tested for the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, cytotoxicity of mouse peritoneal macrophage, and antibacterial activities.

• 公益社団法人　日本薬学会の論文

著者

• PROKSCH Peter

  Institut fur pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf

• DENG Zhiwei

  Analytical and Testing Center, Beijing Normal University

• LIN Wenhan

  State Key Laboratory of Natural and Biomimetic Drugs, Peking University

• Lin Wenhan

  State Key Laboratory Of Natural And Biomimetic Drugs Peking University

• Deng Zhiwei

  Analytical And Testing Center Beijing Normal University

• Proksch Peter

  Institut Fur Pharmazeutische Biologie Und Biotechnologie Heinrich-heine-universitat Dusseldorf

• Yan Pengcheng

  State Key Laboratory of Natural and Biomimetic Drugs, Peking University

• van Ofwegen

  National Museum of Natural History Naturalis, The Netherlands

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