Synthesis and Antiviral Activities of Synthetic Glutarimide Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.
著者
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Ji Xing-yue
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Zhong Zhao-jin
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Xue Si-tu
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Meng Shuai
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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He Wei-ying
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Gao Rong-mei
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Li Yu-huan
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Li Zhuo-rong
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical Co
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Li Zhuo-rong
Institute Of Medicinal Biotechnology Chinese Academy Of Medical Science And Peking Union Medical Col
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Li Yu-huan
Institute Of Medicinal Biotechnology Chinese Academy Of Medical Sciences And Peking Union Medical College
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Meng Shuai
Institute Of Medicinal Biotechnology Chinese Academy Of Medical Sciences And Peking Union Medical College
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Meng Shuai
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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Zhong Zhao-jin
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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Ji Xing-yue
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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Li Yu-huan
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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Gao Rong-mei
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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Xue Si-tu
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
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He Wei-ying
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College
関連論文
- Synthesis and Antiviral Activities of Synthetic Glutarimide Derivatives
- Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs
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