Chemical Constituents from Aphanamixis grandifolia
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概要
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(23E)-25-Methylcycloart-23-en-3β-ol (1), a cycloartane-type triterpenoid featuring an unusual skeleton of 31 carbon atoms, (17E)-cycloart-17,26-dien-3β-ol (2), a new cycloartane-type triterpenoid, and the other two new compounds 4R-hydroxy-4-(9S-hydroxy-12-methylhexan-6-yl)-3-methylcyclopent-2-enone (6) and 7-hydroxy-5-(2′-hydroxy-4′,5′-dimethoxyphenyl)-2-methoxy-6-methyl-1,4-naphthoquinone (7), together with three known cycloart-3β-ol triterpenoids (3—5) were isolated from aerial parts of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analysis, and that of 1 was confirmed by single-crystal X-ray diffraction. The absolute configuration of two carbon stereocenters of compound 6 was determined to be 4R,9S by means of circular dichroism (CD) and auxiliary chiral α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) derivatives, respectively. The compound 3 exhibited significant cytotoxicities against HL-60, Hep G2 and HeLa, and compounds 1, 2, 5, 6 and 7 exhibited modest cytotoxicities. No activity of compound 4 could be due to the absence of the hydroxyl group at C-24.
著者
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Gao Kun
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, La
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Gao Kun
State Key Lab. Of Applied Organic Chemistry Coll. Of Chemistry And Chemical Engineering Lanzhou Univ
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Liu Quan
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, La
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Chen Chao-Jun
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, La
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Shi Xiang
School of Life Sciences, Lanzhou University
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Zhang Li
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, La
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Chen Hui-Juan
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, La
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Zhang Li
State Key Lab. Of Applied Organic Chemistry Coll. Of Chemistry And Chemical Engineering Lanzhou Univ.
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Chen Hui-Juan
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Gao Kun
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Zhang Li
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Chen Chao-Jun
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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