Synthesis, Cytotoxicity and Pro-apoptosis of Novel Benzoisoindolin Hydrazones as Anticancer Agents
スポンサーリンク
概要
- 論文の詳細を見る
A series of benzoisoindolin hydrazones as analogues of natural lignan diphyllin were synthesized and the structures of these compounds were established by 1H-NMR, 13C-NMR, Mass and high resolution (HR)-MS. The compounds were evaluated for in vitro cytotoxicity against KB, A549 and HCT-116 cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 4 possessed the highest growth inhibitory effect. Significant apoptosis of HCT-116 cells treated with compound 4 was observed by Hoechst33342-propidium iodide (PI) and acridine orange (AO)-ethidium bromide (EB) staining assay. Western blot analysis disclosed that compound 4 induced apoptosis via the mitochondrial pathway accompanied by an increased expression of Bax and a decreased expression of Bcl-2.
- 社団法人 日本薬学会の論文
著者
-
WANG Dan
Institute of Process Engineering, Chinese Academy of Science
-
Zhu Li
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
-
Zhao Yu
Institute of Nautical Medicine, Nantong University
-
Hui Jie
Institute of Nautical Medicine, Nantong University
-
Fang Jing-Huai
School of Science, Nantong University
-
Zhao Xiao-Dong
School of Electromechanical Engineering, Zhejiang Ocean University
-
Zhao Yu
Institute Of Materia Medica College Of Pharmaceutical Sciences Zhejiang University
-
Wang Dan
Institute Of Inorganic Synthesis Faculty Of Engineering Yamanashi University
-
Zhu Li
Institute Of Genetics And Developmental Biology Chinese Academy Of Sciences
-
Zhu Li
Institute of Nautical Medicine, Nantong University
-
Wang Dan
Institute of Nautical Medicine, Nantong University
関連論文
- Detecting QTLs for plant architecture traits in cucumber (Cucumis sativus L.)
- A Novel Open-framework Cerium Sulfate Hydrate : Synthesis and Characterization
- Synthesis and Characterization of the First Organically Templated Layered Cerium Phosphate Fluoride : [(CH_2)_2(NH_3)_2]_[Ce^F_3(HPO_4)]
- A Novel Layered Zirconium Phosphate [NH_4]_2[Zr(OH)_3(PO_4)] Synthesized through Non-aqueous Route
- Non-aqueous Synthesis and Structure of a Novel Monodimensional Zirconium Phosphate : [NH_4]_3[Zr(OH)_2(PO_4)(HPO_4)]
- Synthesis, Cytotoxicity and Pro-apoptosis of Novel Benzoisoindolin Hydrazones as Anticancer Agents
- Self-assembly of a Novel Manganiferous Coordination Polymer with Mixed Ligands
- Three Antigenic Regions in p17 of Human Immunodeficiency Virus Type 1 ( HIV-1 ) Revealed by Mouse Monoclonal Antibodies and Human Antibodies in HIV-1 Carriar Sera
- In Situ Ligand Synthesis for a Novel 1-D Mn Coordination Polymer
- Target-guided isolation and purification of antioxidants from Selaginella sinensis by offline coupling of DPPH-HPLC and HSCCC experiments
- Purification and identification of antiviral components from Laggera pterodonta by high-speed counter-current chromatography