Synthesis of 2-Oxo/Thioxooctahydroquinazolin-5-one Derivatives and Their Evaluation as Anticancer Agents

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概要

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• An environment friendly method for the synthesis of 2-oxo/thioxooctahydroquinazolin-5-one derivatives has been devised using Ceric ammonium nitrate (CAN) as catalyst and polyethylene glycol (PEG) as solvent. The cytotoxic effect of these compounds was studied on U87 human glioma cells, compounds 4c, 4d and 4e are found to exhibit excellent activity at a concentration as low as 0.06 μg/ml.

• 社団法人 日本薬学会の論文

著者

• Kidwai Mazaahir

  Green Research Laboratory, Department of Chemistry, University of Delhi

• Bhatnagar Divya

  Green Research Laboratory, Department of Chemistry, University of Delhi

• Kumar Rakesh

  Medicinal and Pharmaceutical Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research,

• Luthra Pratibha

  Medicinal and Pharmaceutical Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research,

• Kumar Rakesh

  Medicinal and Pharmaceutical Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi

• Luthra Pratibha

  Medicinal and Pharmaceutical Chemistry Laboratory, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi

関連論文

• Synthesis of 2-Oxo/Thioxooctahydroquinazolin-5-one Derivatives and Their Evaluation as Anticancer Agents

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