Combination of Baicalein and Amphotericin B Accelerates Candida albicans Apoptosis
スポンサーリンク
概要
- 論文の詳細を見る
Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates of C. albicans. Synergistic activities were determined using the checkerboard microdilution assay based on the fractional inhibitory concentration indices. Combination of BE and AmB accelerated C. albicans apoptosis accompanied with an increase of reactive oxygen species (ROS). Moreover, AmB increased the caspase activity and expression of the corresponding gene CaMCA1 in C. albicans. These effects were enhanced in the presence of BE. Deletion of CaMCA1 clearly attenuated AmB-induced apoptosis, indicating the involvement of CaMCA1-mediated caspase pathway in AmB-induced apoptosis and the synergistic action.
著者
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Fu ZiJin
School of Pharmacy, Second Military Medical University, P.R. China
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Lu Hui
School of Pharmacy, Second Military Medical University, P.R. China
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Zhu ZhenYu
School of Pharmacy, Second Military Medical University, P.R. China
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Yan Lan
School of Pharmacy, Second Military Medical University, P.R. China
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Jiang YuanYing
School of Pharmacy, Second Military Medical University, P.R. China
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Cao YingYing
School of Pharmacy, Second Military Medical University, P.R. China
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Zhu Zhenyu
School Of Pharmacy Second Military Medical University
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Yan Lan
School Of Pharmacy Second Military Medical Univ. P.r. China
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Fu ZiJin
School of Pharmacy, Second Military Medical University, P. R. China
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Jiang YuanYing
School of Pharmacy, Second Military Medical University, P. R. China
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Lu Hui
School of Pharmacy, Second Military Medical University, P. R. China
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Cao YingYing
School of Pharmacy, Second Military Medical University, P. R. China
関連論文
- Combination of Baicalein and Amphotericin B Accelerates Candida albicans Apoptosis
- Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats
- Inhibitory Effect of Shikonin on Candida albicans Growth