A New Commercially Viable Synthetic Route for Donepezil Hydrochloride: Anti-Alzheimers Drug

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概要

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• An economical new process has been developed for the synthesis of donepezil hydrochloride (1) an anti-Alzheimers drug. The process involves Darzen reaction of pyridine-4-carboxaldehyde and 2-bromo-5,6-dimethoxy indanone affording epoxide 5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2′-oxiran]-1(3H)-one (4) as a key intermediate. The one-pot deoxygenation of 4 and hydrogenation of the aryl moiety in high yield improved the overall yield of the process.

• 公益社団法人　日本薬学会の論文

著者

• Dubey Shailendra

  Chemical and Pharma Research Department, Jubilant Organosys Limited

• Kharbanda Manita

  Chemical and Pharma Research Department, Jubilant Organosys Limited

• Dubey Sushil

  Chemical and Pharma Research Department, Jubilant Organosys Limited

• Mathela Chandra

  Department of Chemistry, Kumaun University

関連論文

• A New Commercially Viable Synthetic Route for Donepezil Hydrochloride: Anti-Alzheimers Drug

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