金クラスターおよびナノ粒子の無機バイオコンジュゲート : ―簡単な歴史と最近の進歩―

概要

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In this review, we focus on the recent development of conjugates between nanoparticles (NPs) and biomolecules such as DNAs, as well as a brief history for inorganic bioconjugate chemistry. NP-biomolecule combination is heterogeneous and thus challenging. This research area was begun about a decade ago as a basic attempt to align AuNPs along DNA. Today, NP–DNA is a current topic whose developments can be applied in diagnosis, new devices, and drug delivery systems. Among these, the nanoscaled patterning of mesoscale NPs is the vital target of current material science, in which the conjugation of gold (Au) NPs and biomolecules is gaining immense importance. The positioning or alignment of NPs on the desired points of highly constructed DNA architectures is an important step for “DNA lithography” that leads to new electronic and optical devices. This review also introduces the current topics in the DNA architecture and its application for AuNP alignment.