Reduction in Intraocular Pressure by the Instillation of Eye Drops Containing Disulfiram Included with 2-Hydroxypropyl-β-cyclodextrin in Rabbit
スポンサーリンク
概要
- 論文の詳細を見る
We have studied the effect of disulfiram (DSF) solution containing 2-hydroxypropyl-β-cyclodextrin and hydroxypropylmethylcellulose (DSF eye drops) on intraocular pressure (IOP) in experimentally induced ocular hypertension in rabbits. In both in vitro and in vivo transcorneal penetration experiments using rabbit corneas, only diethyldithiocarbamate (DDC) was detected in the aqueous humor, while DSF was not detected. The amount of DDC penetration for 0.25% DSF eye drops was about 4-fold that for 0.1% DSF eye drops in in vivo transcorneal penetration experiments. The elevation in IOP was induced by the rapid infusion of 5% glucose solution (15 ml/kg of body weight) through the marginal ear vein, and IOP was measured with an electronic tonometer. The induced elevation in IOP was reduced by the instillation of 0.1—0.5% DSF eye drops, and the IOP-reducing effect increased with the increase in DSF concentration in the drops. Nitric oxide (NO) levels increased in the aqueous humor following the infusion of the 5% glucose solution, and this increase was also suppressed by the instillation of DSF eye drops. In conclusion, the present study demonstrates that the instillation of DSF eye drops has an IOP-reducing effect in rabbits with experimentally induced ocular hypertension, probably caused by the suppression of NO production.
- 公益社団法人 日本薬学会の論文
著者
-
Ito Yoshimasa
Faculty Of Pharmaceutical Sciences Kinki University
-
Nagai Noriaki
Faculty of Pharmacy, Kinki University
-
Shimomura Yoshikazu
Department of Ophthalmology, Kinki University School of Medicine
-
Shimomura Yoshikazu
Department Of Ophthalmology Kinki University School Of Medicine
関連論文
- Preparation and in Vivo Ocular Absorption Studies of Disulfiram Solid Dispersion
- Pharmacokinetics and First-Pass Effect of Bromhexine in Rats
- Inhibitory Effect of Valproic Acid on Metabolic Clearance of Carbamazepine Epoxide
- Drug Interaction between Phenytoin and Allopurinol
- Effects of Anticonvulsants on Plasma Levels and Entero-Hepatic Circulation of Valproic Acid and on Hepatic Drug Metabolizing Enzyme Acitivities in Rats
- In Vitro Stability of Insulin-Loaded Erythrocytes after Freezing Storage
- Encapsulation of Porcine Insulin in Rabbit Erythrocytes and Its Disposition in the Circulation System in Normal and Diabetic Rabbits
- Thermodynamic Study on Enhancement of Percutaneous Penetration of Drugs by Azone^[○!R]
- A Pharmacokinetic Model for Percutaneous Absorption of Valproic Acid and Prediction of Drug Disposition
- The Percutaneous Absorption of Propranolol and Prediction of the Plasma Concentration
- ENCAPSULATION OF HUMAN UROKINASE IN RABBIT ERYTHROCYTES AND ITS DISPOSITION IN THE CIRCULATION SYSTEM IN RABBITS
- PERCUTANEOUS ABSORPTION OF VALPROIC ACID AND ITS PLASMA CONCENTRATION AFTER APPLICATION OF OINTMENT
- PREDICTION OF PLASMA CONCENTRATION PROFILE DURING SINGLE AND REPEATED SKIN APPLICATIONS OF INDOMETHACIN AND ITS CALCIUM SALT OINTMENTS
- PHARMACOKINETICS OF FORMATION, CONVERSION AND EXCRETION OF SOME METABOLITES OF HYDRALAZINE AND THEIR HYPOTENSIVE EFFECT IN RATS
- ABSORPTION OF INDOMETHACIN AND ITS CALCIUM SALT THROUGH RAT SKIN : EFFECT OF PENETRATION ENHANCERS AND RELATIONSHIP BETWEEN IN VIVO AND IN VITRO PENETRATION
- Immunohistochemical Study of Calpain-Mediated α-Crystallin Proteolysis in the UPL Rat Hereditary Cataract
- Reduction in Intraocular Pressure by the Instillation of Eye Drops Containing Disulfiram Included with 2-Hydroxypropyl-β-cyclodextrin in Rabbit
- Connective Tissue Growth Factor Cooperates with Fibronectin in Enhancing Attachment and Migration of Corneal Epithelial Cells
- The Use of Competitive PCR for Quantitation of HSV-1 DNA
- The Effect of Immunization with Herpes Simplex Virus Glycoprotein D Fused with Interleukin-2 against Murine Herpetic Keratitis
- Corneal Changes in Spondyloepiphyseal Dysplasia Tarda
- Novel polymorphisms in the βig-h3 gene
- Detection of HSV mRNA Using Reverse Transcription-polymerase Chain Reaction for Diagnosis in Murine Herpetic Keratitis Model
- PHARMACOKINETICS OF TOPICALLY APPLIED CIPROFLOXACIN IN RABBIT TEARS
- Oscillatory Potentials with Repeated-Flash Electroretinography
- Herpes Simplex Virus-2 Quantification by Real-time Polymerase Chain Reaction in Acute Retinal Necrosis
- Iontophoresis for Enhancing Penetration of Dermatologic and Antiviral Drugs
- Correlation between Hyper-Sensitivity to Hydrogen Peroxide and Low Defense against Ca2+ Influx in Cataractogenic Lens of Ihara Cataract Rats
- A Case of Severe Stevens-Johnson Syndrome Successfully Treated by Osteo-odonto-keratoprosthesis Surgery
- The effects of binocular suture and dark rearing on the induction of c-fos protein in the rat visual cortex during and after the critical period
- Case of Bilateral Multiple Herpetic Epithelial Keratitis Manifested as Dendriform Epithelial Edema During Primary Kaposi's Varicelliform Eruption
- Implantation of a Keratoprosthesis of Novel Design in Rabbits
- Core Vitrectomy Preceding Triple Corneal Procedure in Patients at High Risk for Increased Posterior Chamber Pressure
- Reactivation of Herpes Virus After Lamellar Keratoplasty
- A Case of Herpetic Keratitis Induced by Electric Stimuli to a Facial Nerve
- Excimer Laser Photokeratectomy Reactivates Latent Herpes Simplex Virus
- A Case of Corneal Dystrophy Treated with Automated Lamellar Therapeutic Keratoplasty
- Three Cases of "Domino" Keratoplasty
- SUSCEPTIBILITY OF CULTURED RABBIT CORNEAL EPITHELIAL CELLS TO VARIOUS HERPES SIMPLEX VIRUS ISOLATES
- Pharmacokinetic and Pharmacodynamic Evaluation of the Anti-cataract Effect of Eye Drops Containing Disulfiram and Low-Substituted Methylcellulose Using ICR/f Rats as a Hereditary Cataract Model
- Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops