Analysis of the Fusion Protein Gene of Newcastle Disease Viruses Isolated in Japan
スポンサーリンク
概要
- 論文の詳細を見る
The complete nucleotide sequences of the fusion (F) protein gene of Newcastle disease viruses (NDV) isolated in Japan from 1930 to 2007 (45 strains total) were determined and genetically analyzed. In the deduced amino acid sequences of fusion protein, the 5 potential asparagine-linked glycosylation sites and 10 cysteine residues were all conserved in the NDV examined in this study. The major epitopes involved in virus neutralization are conserved in most of the NDV strains isolated in Japan except a few strains. By virus neutralization test, no major antigenic differences were observed among representative strains of each genotype in Japan. All chickens vaccinated with the B1 strain survived without clinical signs after challenge with 2 NDV strains isolated in Japan (velogenic strains, JP/Ibaraki/2000 and JP/Kagoshima/91), which possess amino acids substitutions involved in virus neutralization in the F protein gene.
著者
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MASE Masaji
National Institute of Animal Health
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MURAYAMA Kazunori
Chuo Animal Hygiene Service Center
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KARINO Ayako
Domestic Livestock Disease Identification Office, Shimane Prefecture
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INOUE Toshikazu
National Institute of Animal Health
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Inoue Toshikazu
National Inst. Animal Health Ibaraki
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Mase Masaji
National Inst. Animal Health Ibaraki
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