Dietary Supplementation with Probiotic Fermented Tetra-Herbal Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks

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概要

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• Herbs including Curcuma longa, Houttuynia cordata, Prunus mume and Rubus coreanus have potential immune enhancing and antimicrobial effects. Probiotics also have antibacterial effects and some are important in regulating the immune system. The aims of the present study were to evaluate the immune enhancing effects of probiotic fermented tetra-herbal combination (PFH) in broiler chicks, and to demonstrate the prophylactic effect of PFH against Salmonella Gallinarum in experimentally infected broiler chicks as initial step towards the development of feed supplements for the promotion of immune activity and disease prevention. Continuous ingestion of PFH markedly increased lysozyme activity in serum and spleen, peripheral blood mononuclear cell (PBMC) proliferation, the CD4+:CD8+ T lymphocyte ratio in spleen and antibody production level in broiler chicks. Conversely, prostaglandin E2 synthesis in serum and PBMC culture medium of PFH-fed chicks were significantly decreased compared with the control group in a dose-dependent manner. In experimentally S. Gallinarum infected chicks, mortality was delayed in 2% PFH-fed chicks. Moreover, survival rates in the 2% PFH-fed group remained the highest among all the trial groups throughout the experimental period. Taken together, these findings suggest that PFH enhances immune activity in broiler chicks and increases survivability against Salmonella Gallinarum in experimentally infected broiler chicks, likely because of potent stimulation of nonspecific immune responses.

• 社団法人　日本獣医学会の論文

著者

• Jung Bock-Gie

  College of Veterinary Medicine, Chonnam National University

• Ko Jae-Hyung

  College of Veterinary Medicine, Chonnam National University

• Lee Bong-Joo

  College of Veterinary Medicine, Chonnam National University

関連論文

• Dietary Supplementation with Probiotic Fermented Tetra-Herbal Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks
• Immune-Enhancing Effect of Fermented Maesil (Prunus mume Siebold & Zucc.) with probiotics against Bordetella bronchiseptica in Mice
• Immunoprophylactic Effects of Administering Honeybee (Apis melifera) Venom Spray against Salmonella Gallinarum in Broiler Chicks
• Oxygenated Drinking Water Enhances Immune Activity in Pigs and Increases Immune Responses of Pigs during Salmonella Typhimurium Infection

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