Molecular Characterization of Interleukin-1Beta in the Tammar Wallaby (Macropus eugenii)

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概要

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• Interleukin-1beta (IL-1β) plays a significant role in the onset and pathogenesis of inflammation in mammalian hosts. Although well characterised in a range of vertebrate species, little is known about this important cytokine in marsupial mammals. We report here the molecular cloning and characterisation of IL-1β in the tammar wallaby (Macropus eugenii). M. eugenii IL-1β has an open-reading frame of 813 nucleotides, coding for a putative protein of 270 amino acids to the termination codon. The IL-1 family motif and potential caspase cleavage site (necessary for production of the mature protein) is also present in the sequence. Molecular characterisation of tammar wallaby IL-1β provides fundamental information necessary to progress the study of functional immune responses in this unique group of mammals.

著者

• YOUNG Lauren

  Marsupial Immunology Research Laboratory, Centre for Environmental Management CQUniversity Australia

• HARRISON Gavan

  School of Science, Food and Horticulture, University of Western Sydney

関連論文

• Molecular Characterization of Interleukin-1Beta in the Tammar Wallaby (Macropus eugenii)

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