Effects of Mycotoxins on Chemiluminescent Response and Cytokine mRNA Expression of Bovine Neutrophils

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概要

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• The effects of aflatoxin B1 (AFB1), aflatoxin M1 (AFM1), deoxynivalenol (DON) and zearalenone (ZEA) on the viability, chemiluminescent (CL) response and expression of cytokine mRNA of bovine neutrophils (PMNs) were evaluated. The opsonized zymosan (OPZ)-stimulated CL response of PMNs was significantly (P<0.05) decreased by AFB1 (>50 pg/ml), AFM1 (>50 pg/ml) and ZEA (>50 ng/ml). The phorbol myristate acetate (PMA)-stimulated CL response PMNs was significantly (P<0.05) decreased by AFB1 (>0.5 pg/ml), AFM1 (>50 ng/ml), ZEA (>500 pg/ml) and DON (>5 pg/ml). Treatment with AFB1 resulted in reduction in the mRNA expression of interleukin-1β and tumor necrosis factor-α of PMNs stimulated with OPZ and PMA. These results suggest that these four mycotoxins have inhibitory effects on the function of bovine PMNs.

著者

• NAGAHATA Hajime

  Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

• HIGUCHI Hidetoshi

  Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

• WADA Kenji

  Yamagata Prefecutural Federation of Agricultural Mutual Aid Associations

• NABAE Akiko

  Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

関連論文

• Effects of Mycotoxins on Chemiluminescent Response and Cytokine mRNA Expression of Bovine Neutrophils
• A Retrospective Survey of the Prevalence of Complex Vertebral Malformation Carriers in 9 Holstein Dairy Herds in Hokkaido, Japan

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