Effects of Enfonidipine Hydrochloride in Dogs with Experimental Supraventricular Tachyarrhythmia
スポンサーリンク
概要
- 論文の詳細を見る
It is required not to increase the ventricular rate and to preserve the ventricular systolic function in treating supraventricular tachyarrhythmia (SVTA). The objective of this study is to investigate whether or not Efonidipine hydrochloride (EH), a T and L dual type Ca2+ channel blocker, suppresses the increasing ventricular rate without reducing the ventricular systolic function using canine SVTA models by rapid atrial pacing (RAP) method. Clinically healthy 14 beagles were used. The 14 dogs were randomly assigned to the EH-administered group (EH group, n=7) and non-EH-administered group (control group, n=7). The EH group was orally-administered EH at 5 mg/kg SID during RAP. On the other hand, the control group was applied RAP without oral administration of EH. Duration of RAP was for three weeks for both groups. The ventricular rate for the EH group was significantly lower than that for the control group. The left ventricular- fractional shortening for the control group declined significantly compared to baseline. Those for the EH group did not show any changes over time and were significantly higher than the control group. The ratio between pre-ejection period and ejection for the EH group were significantly lower than those of the control group. In conclusion, the study demonstrated that EH suppresses the increasing ventricular rate without reducing the ventricular systolic function in canine SVTA model. Therefore, EH is expected to become a new treatment for canine SVTA.
著者
-
MACHIDA Noboru
Laboratory of Veterinary pathology, Tokyo University of agriculture and Technology
-
Fukushima Ryuji
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology
-
Tanaka Ryou
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology
-
Matsumoto Hirotaka
Laboratory of Internal Medicine, Nippon Veterinary and Life Science University
-
HIROSE Hisashi
Laboratory of Internal Medicine, Nippon Veterinary and Life Science University
-
YAMANE Yoshihisa
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology
-
KOYAMA Hidekazu
Laboratory of Internal Medicine, Nippon Veterinary and Life Science University
-
Machida Noboru
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
関連論文
- Evaluation of Plasma N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) Concentrations in Dogs with Mitral Valve Insufficiency
- Effects of Enfonidipine Hydrochloride in Dogs with Experimental Supraventricular Tachyarrhythmia
- O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- ABSENCE OF IN VIVO GENOTOXICITY AND LIVER INITIATION ACTIVITY OF DICYCLANIL
- 乳牛における子宮角超音波画像の解析
- Effect of Diet on Cardiovascular System in Healthy Beagle Dogs
- Influence of Preemptive Analgesia with Meloxicam before Resection of the Unilateral Mammary Gland on Postoperative Cardiovascular Parameters in Dogs
- The Assessments of Factors that Affect Glomerular Filtration Rate and Indirect Markers of Renal Function in Dogs and Cats
- The Evaluation of a Single Sampling Method for Estimation of Plasma Iohexol Clearance in Dogs and Cats with Various Kidney Functions
- Evaluation of the Measurement of Serum Cystatin C by an Enzyme-Linked Immunosorbent Assay for Humans as a Marker of the Glomerular Filtration Rate in Dogs
- Epidemiological, Clinical and Pathological Features of Primary Cardiac Hemangiosarcoma in Dogs: A Review of 51 Cases
- Extreme Tetralogy of Fallot in a Dog