生物活性リコポジウムアルカロイドの探索と不斉合成

概要

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Lycopodium alkaloids have been attracting many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics. Our recent chemical investigation on Lycopodium plants, aiming to find novel seed– and lead–molecules for drug development, resulted in the isolation of a number of biologically active alkaloids. Among them, two Fawcettimine–type alkaloids, lycoposerramines–B and –C, four Phlegmarine–type alkaloids, lycoposerramines–V, –W, –X, and –Z, and five Quinolizidine–type alkaloids involving cernuine and cermizine–D, have been synthesized to determine the structures including their absolute configuration.