Negative Chemical Ionization Mass Spectrometry of Nucleosides

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概要

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• Negative chemical ionization(NCI) mass Spectra of a number of nucleosides, halogenonucleosides and purine and pyrimidine bases have been studied using a H2/N2O mixed gas as a reagent gas. In most of the nucleosides, each base fragment ion (b)- peak was the strongest, (M-H)- ion peak was weak or non-existent, and a significant (b+O)- ion was found. It seems that formation of the (b+O)- ion roughly correlates to the LUMO energy of corresponding base. A group of low mass ions (m/z 71, 58, 45) which was attributed to the sugar moiety cleavage was clearly found in ribonucleosides, but not in 2′-deoxyribonucleosides. NCI spectra of the halogenonucleosides showed the prominent peaks of halogen ions (often the base peak). Molecular ion M- was formed from these halogenonucleosides. The process of negative ion production of nucleosides was discussed.

• 日本質量分析学会の論文

著者

• Seto Hiroshi

  Tokyo Metropolitan Research Laboratory Of Public Health

• Okuda Taisuke

  College of Science and Technology, Nihon University

• Takesue Tomoyuki

  College of Science and Technology, Nihon University

• Ikemura Tadashi

  College of Science and Technology, Nihon University

関連論文

• Hydroxylation of Deoxyguanosine at the C-8 Position in the Thiosulfate-Hydrogen Peroxide Reaction System. Evidence of Hydroxyl Radical Generation in the System
• Reaction of Malonaldehyde with Adenosine. Formation of a Novel Adduct Containing a Dioxazatricycloundecene Residue in the Base-pairing Region
• Negative Chemical Ionization Mass Spectrometry of Nucleosides
• Reaction of malonaldehyde with nucleic acid. I. Formation of fluorescent pyrimido(1,2-a)purin-10(3H)-one nucleosides.
• Reaction of malonaldehyde with nucleic acid. II. Formation of fluorescent pyrimido(1,2-a)purin-10(3H)-one mononucleotide.

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