A New Method for Multi-Dimensional Analysis of Circulation and Metabolism: : Application of Respiratory Mass Spectrometer and Computer System

概要

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An improved mass spectrometer-computer system has been developed for a simultaneous measurement of multi-variables and multi-dimensional analysis of the respiration, circulation and metabolism functions.The system is composed of a respiratory mass spectrometer, a pneumotachometer, a heart rate meter, a microcomputer system which is combined with a specially designed analogue processor. A bicycle ergometer and a treadmill are used for exercise test. Measurable factors are instantaneous change of respiratory gas concentrations, breathing flow, heart rate, ventilation rate VE, oxygen uptake rate VO2, carbon dioxide output rate VCO2, cardiac output Qe, all kinds of lung volumes and thier derivatives. VE, VO2, VCO2 are calculated in breath by breath with an improved precision by means of real time processing of gas concentrations and breathing flow. Qc and its derivatives can be intermittently measured by means of C2H2 rebreathing method. With employing the present system, almost all kinds of respiration factors can be simultaneously measured together with circulation and metabolism factors, and especially the analysis of transient response to the applied exercise became accessible. Thus the more advanced measurement was attained for the study of respiration physiology and for the clinical applications.
日本質量分析学会の論文