Pancreatic β-cell signaling: toward better understanding of diabetes and its treatment

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概要

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• Pancreatic β-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the β-cells and/or a decrease in the β-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and β-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.(Communicated by Hiroo IMURA, M.J.A.)

• 日本学士院の論文

著者

• MINAMI Kohtaro

  Division of Cellular and Molecular Medicine Kobe University Graduate School of Medicine

• SEINO Susumu

  Division of Cellular and Molecular Medicine Kobe University Graduate School of Medicine

• SHIBASAKI Tadao

  Division of Cardiovascular Biology, Center for Biomedical Science, Chiba University School of Medici

• Shibasaki Tadao

  Division Of Cardiovascular Biology Center For Biomedical Science Chiba University School Of Medicine

• SHIBASAKI Tadao

  Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine

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