Investigation on the Interaction of Prulifloxacin with Human Serum Albumin: A Spectroscopic Analysis

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概要

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• The interaction between prulifloxacin (PUFX) and human serum albumin (HSA) was investigated under simulated physiologic conditions with fluorescence spectra. The fluorescence quenching process of HSA may be mainly governed by a static quenching mechanism. The apparent binding constant Kb between PUFX and HSA at different temperatures were 2.08±1.04, 2.74±0.50, and 4.98±1.61×108 l/mol. The thermodynamic parameters, with a negative value of ΔG0, revealed that the binding is a spontaneous process. A binding distance R of 1.19 nm between donor and acceptor was obtained from the Fŏrster energy transfer theory.

著者

• YU Zhang

  Department of Biophysics, Shanghai Medical University

• Huang Ya-Bei

  Department of Chemistry, Huaibei Coal Normal College

• Wang Shi-Jun

  Huaibei Occupational Disease Prevention and Cure Hospital

• Zi Yan-Qin

  Department of Chemistry, Huaibei Coal Normal College

• Gao Xiao-Yan

  Department of Chemistry, Huaibei Coal Normal College

• Tang Ying-Cai

  Department of Chemistry, Huaibei Coal Normal College

• Zhang Da-Ming

  Department of Chemistry, Huaibei Coal Normal College

関連論文

• Investigation on the Interaction of Prulifloxacin with Human Serum Albumin: A Spectroscopic Analysis
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