Cytotoxicity and Utility of 1-Indanone in the Synthesis of Some New Heterocycles

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概要

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• Benzo[d]imidazole 3 and 1,2,4-triazin-5(2H)-one 6 were prepared by the reaction of starting ethyl (3-hydroxy-1H-inden-2-yl)(oxo)-acetate 2 with o-phenylenediamine and thiosemicarbazide respectively. Reaction of 1,4-dihydro-1-phenylindeno[1,2-c]pyrazole-3-carbohydrazide 8 with phenylisothiocyanate gave thiosemicarbazide 9, and its reaction with chloroacetic acid or phenacylbromides led to the formation of thiazolidinone-4-one 10 or 1,3-thiazoles 12a, b. The reactivity of hydrazide 8 towards fluorinated aldehyde, phthalic anhydride, and hydrazonoyl chlorides 15a, b was studied to give fluorinated hydrazones, imide bis-hydrazones 13—16. The newly synthesized compounds were screened for their cytotoxic activities and compounds 6, 8, 9 and 10 were found the most potentially cytotoxic. The detailed synthesis, spectroscopic and biological data are reported.

• 社団法人 日本薬学会の論文

著者

• Badria Farid

  Pharmacognosy Department, Faculty of Pharmacy, Mansoura University

• Mohamed Hanan

  Applied Organic Chemistry Department, National Research Centre, Egypt

• Dawood Kamal

  Chemistry Department, Faculty of Science, Cairo University

• Hegazi Bahira

  Applied Organic Chemistry Department, National Research Centre, Egypt

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