Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities

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A new polyhydroxy sterol ester, (25S)-5α-cholestane-3β,6α,7α,8,15α,16β-hexahydroxyl-26-O-14′Z-eicosenoate (1), together with seven known steroid derivatives (2—8), were isolated from the EtOH extract of the whole body of China Sea starfish Asterina pectinifera. The structure of 1 was determined by using extensive spectra analysis (IR, 1D and 2D NMR, and MS), chemical degradation, and comparison with the known compound (25S)-5α-cholestane-3β,6α,7α,8,15α,16β,26-heptol (2). All the isolates were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) and their cytotoxicity against human liver carcinoma HepG2 cell line in vitro. Compounds 3—6, and 8 exhibited antiviral activity against HSV-1 virus with the minimal inhibitory concentration (MIC) values of 0.2, 0.05, 0.2, 0.22, and 0.07 μM, respectively. While compounds 4 and 5 exhibited cytotoxicity against HepG2 cells with IC50 values of 0.2 and 1.6 μM, respectively.