Emdogain® in carcinogenesis: a systematic review of in vitro studies
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概要
- 論文の詳細を見る
Emdogain is a commercial product of unknown composition and is clinically used to induce periodontal regeneration. This study aims to review current knowledge of the in vitro effects of Emdogain on oral tissues and, in particular, factors related to carcinoma. A systematic approach was used to review studies from the Embase and Pubmed databases; a total of 76 studies were included. These comprised in vitro studies of the cytokines in, or regulated by, Emdogain and assays designed to study the effects of EMD on human cells in oral tissues or malignant cells. Several studies have shown that EMD regulates the proliferation, migration, adhesion, gene expression, and cytokine production of (pre-)osteoblasts, periodontal fibroblasts, and gingival fibroblasts. However, the effects of EMD on malignant oral cells are not well understood. EMD seems to have broad regulatory effects on malignant cells and on several carcinoma-related factors. Evidence suggests that patients with premalignant or malignant mucosal lesions should not be treated with EMD. (J Oral Sci 52, 1-11, 2010)
著者
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Salo Tuula
Department Of Diagnostics And Oral Medicine Institute Of Dentistry University Of Oulu
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Sorsa Timo
Department of Cell Biology of Oral Diseases, Biomedicum Helsinki, Institute of Dentistry, University of Helsinki
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Sorsa Timo
Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Institute of Dentistry, University of Helsinki
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Laaksonen Matti
Department of Cell Biology of Oral Diseases, Biomedicum Helsinki, Institute of Dentistry, University of Helsinki
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Salo Tuula
Department of Diagnostics and Oral Medicine, Oulu University Central Hospital, Institute of Dentistry, University of Oulu
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Laaksonen Matti
Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Institute of Dentistry, University of Helsinki
関連論文
- Emdogain® in carcinogenesis: a systematic review of in vitro studies
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- Letter to the Editor concerning "Emdogain® in carcinogenesis: a systematic review of in vitro studies" by Laaksonen M, Sorsa T, Salo T (2010) J Oral Sci 52, 1-11