Evaluating the Validity of Serum Neopterin and Chitotriosidase Levels in Follow-Up Brucellosis Patients

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概要

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• Objective Due to its high morbidity rates, brucellosis -a systemic inflammatory disease, is still an important health problem, particularly in Mediterranean regions. One-third of the patients are characterized with musculoskeletal involvement. Principally in chronic cases, there are difficulties in the follow-up of therapy success. Radiological imaging methods are used in musculoskeletal brucellosis in addition to standard serological tests. Two macrophage products, namely neopterin (NPT) and chitotriosidase (ChT), are used as novel markers in order to reflect the status of inflammatory diseases. In this study, we aimed to test the validity of these markers in follow-up of patients with brucellosis. Patients and Methods A total of 40 brucellosis cases were included in the study and 27 healthy individuals were used as controls. Twenty of the brucellosis patients were presented with sacroiliac joint involvement. A 6-week treatment of doxycycline combined with rifampicin or streptomycin was used to treat brucellosis. Clinical observations and serological outcome were used to determine whether treatment was successful or not. Results All of the 20 brucellosis patients without musculoskeletal involvement healed with the first cure of treatment, but all of the brucella-sacroiliitis patients had to be retreated. In addition to routine testing, serum NPT and ChT levels were evaluated after each treatment. The results presented a clear fall in both NPT and ChT levels in parallel with the serological data of the patients. Conclusion In conclusion, NPT as well as ChT seems to be a useful marker in the follow-up of brucellosis patients and for evaluating the success of therapy.

著者

• Coskun Omer

  Gulhane Military Medical Academy Infectious Disease and Clinical Microbiology Department

• Eyigun Can

  Gulhane Military Medical Academy Infectious Disease and Clinical Microbiology Department

• Oter Sukrü

  Gulhane Military Medical Academy Physiology Department

• Yaman Halil

  Gulhane Military Medical Academy Biochemistry Department

• Kilic Selim

  Gulhane Military Medical Academy Public Health and Epidemiology Department

• Kurt Ismail

  Gulhane Military Medical Academy Biochemistry Department

• KILIC Selim

  Gulhane Medical Academy, Department of Public Health

関連論文

• Evaluating the Validity of Serum Neopterin and Chitotriosidase Levels in Follow-Up Brucellosis Patients
• Relationship of Age, Body Mass Index, Wrist and Waist Circumferences to Carpal Tunnel Syndrome Severity

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