A Case of Familial Pulmonary Mycobacterium avium Complex Disease
スポンサーリンク
概要
- 論文の詳細を見る
We report one Japanese familial line in which there were three pulmonary MAC patients and one suspected patient over two generations, most of whom were diagnosed with the nodular/bronchiectatic type. In all patients, life circumstances and bacterial strains differed at the time of diagnosis. This suggests that the genes thought to affect patient susceptibility to pulmonary MAC disease may be involved in this family line. Comprehensive genotypic analysis of the CFTR gene, HLA typing, and analysis of the NRAMP1 polymorphisms were performed in seven members of this family. The results suggest that female sex and menopause might be associated with onset of pulmonary MAC of the nodular/bronchiectatic type, and HLA-A26 antigen and diabetes mellitus might be involved in disease exacerbations.
著者
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Saito Takefumi
Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi National Hospital
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Shimizu Kei
Department Of Pathology School Of Medicine Kurume University
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KEICHO Naoto
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan
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Keicho Naoto
Department Of Respiratory Diseases Research Institute International Medical Center Of Japan
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Hijikata Minako
Department Of Medical Sciences Toshiba General Hospital
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Hayashihara Kenji
Department Of Internal Medicine National Hospital Organization Ibaraki-higashi Hospital
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MATSUYAMA Masashi
Department of Electrical and Electronic Engineering, Musashi Institute of Technology
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Miura Yukiko
Department of Chemistry, Faculty of Science, Ochanomizu University
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Miura Yukiko
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Kiwamoto Takumi
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Moriya Ataru
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Kokuho Nariaki
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Otsuka Shigeo
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Saito Takefumi
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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Matsuyama Masashi
Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital
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