Microscopic Polyangiitis Accompanied by Pleuritis as the only Pulmonary Manifestation of Occupational Silica Exposure
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概要
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A 68-year-old man, who had worked for processing quartz-containing stones for more than 50 years, complained of low-grade fever and arthralgia. Mediastinal lymph nodes were markedly swollen on chest computed tomography. Pathological findings of the lymph node were compatible with silicosis, with a high titer of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). During follow-up with prednisolone treatment, pleuritis and uveitis developed as manifestations of vasculitis. Thus, he was diagnosed with MPO-ANCA-associated vasculitis with occupational silica exposure, possibly microscopic polyangiitis (MPA). This case is rare, because pleuritis was the only pulmonary manifestation, without interstitial pneumonia, alveolar hemorrhage or glomerulonephritis.
著者
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Hisada Tetsuya
Department Of Internal Medicine National Defence Medical College
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Hara Kei
Department Of Gastroenterology Faculty Of Medicine University Of Tokyo
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Sano Hiroko
Department Of Cellular Differentiation Institute For Frontier Medical Sciences Kyoto University
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Hisada Tetsuya
Department of Respiratory Medicine, Tokyo Teishin Hospital
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Osamura Kou
Department of Respiratory Medicine, Tokyo Teishin Hospital
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Shibuya Hideki
Department of Respiratory Medicine, Tokyo Teishin Hospital
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Kujime Kosei
Department of Respiratory Medicine, Tokyo Teishin Hospital
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Hara Kei
Department of Respiratory Medicine, Tokyo Teishin Hospital
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