Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury
スポンサーリンク
概要
- 論文の詳細を見る
Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF-2 in vivo on wound healing using a CO2 laser, corneal epithelial wounded, rabbit model. Topically applied 25 μg/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovascularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.
- 日本薬学会の論文
著者
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Ma Jisheng
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
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LI Xiaokun
School of Pharmaceutical Science, Wenzhou Medical College
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Li Xiaokun
School Of Pharmaceutical Science Wenzhou Medical College
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Wang Xiaojie
School Of Computer Beijing University Of Posts And Telecommunications
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Zhou Xin
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
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Tian Haishan
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
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Jiao Yue
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
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Zhang Rui
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
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Huang Zhifeng
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical College
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Xiao Jian
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical College
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Zhao Binhai
School of Public Health, Jilin University
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Qian Huanwen
Institute of Radiation Medicine, The Academy of Military Medical Science
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Huang Zhifeng
Key Lab. Biotechnology Pharmaceutical Engineering Wenzhou Medical Coll.
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Xiao Jian
Key Lab. Biotechnology Pharmaceutical Engineering Wenzhou Medical Coll.
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Li Xiaokun
School of Public Health, Jilin University
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Wang Xiaojie
School of Public Health, Jilin University
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