IL-10 Polymorphisms Are Associated With Coronary Artery Lesions in Acute Stage of Kawasaki Disease
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概要
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Background: The literature regarding interleukin (IL)-10 polymorphisms and coronary artery lesions (CALs) in Kawasaki disease (KD) is limited. We investigated whether 3 IL-10 genetic polymorphisms (-1082 A/G, -819 T/C, and -592 A/C) are associated with development of CALs in KD. Methods and Results: The genotyping of IL-10 polymorphisms was conducted for 279 KD children (172 without and 107 with CALs in acute stage). Thirty-three patients had CALs in chronic stage and 74 only with transient CALs. The homozygous variant genotype CC of IL-10-819 and IL-10-592 was associated with 80% (P=0.006) and 79% (P=0.008) reduction in risk of CALs in acute stage, respectively. The C allele of IL-10-819 and IL-10-592 was associated with 34% (P=0.034) and 33% (P=0.044) reduction in risk of CALs in acute stage, respectively. Compared with ATA haplotype (adjusted odds ratio (AOR) 0.63, P=0.029) or non-ACC haplotype (AOR 0.64, P=0.033), ACC haplotype was associated with a significantly reduced risk for CALs in acute stage, but not for CALs in chronic stage. Compared with non-ATA haplotype (AOR 1.53, P=0.034), ATA haplotype was associated with a significantly increased risk of CALs, except for CALs in the chronic stage. Conclusions: The effects of IL-10 gene polymorphism on CALs in acute KD are important. The persistence of CALs in chronic stage depends much more on other factors such as the times of intravenous immunoglobulin treatment. (Circ J 2010; 74: 983 - 989)
著者
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Weng Ken-Pen
Department of Pediatrics, Kaohsiung Veterans General Hospital, National Yang-Ming University
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Hsieh Kai-Sheng
Department of Pediatrics, Kaohsiung Veterans General Hospital, National Yang-Ming University
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Hwang Yu-Tung
Department of Pediatrics, Kaohsiung Veterans General Hospital, National Yang-Ming University
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Huang Shih-Hui
Department of Nursing, Fooyin University
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Lai Tsung-Jen
Institute of Biomedical Sciences, National Sun Yat-Sen University
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Yuh Yeong-Seng
Department of Pediatrics, Cathay General Hospital
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Hou Yu-Yi
Department of Otolaryngolog, Kaohsiung Veterans General Hospital
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Lin Chu-Chuan
Department of Pediatrics, Kaohsiung Veterans General Hospital, National Yang-Ming University
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Huang Shih-Chen
Department of Medical Education and Research, Kaohsiung Veterans General Hospital
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Chang Chian-Kai
Department of Animal Science and Biotechnology, Tunghai University
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Lin Ming-Wei
Institute of Public Health, National Yang-Ming University
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Ger Luo-Ping
Institute of Biomedical Sciences, National Sun Yat-Sen University
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