Molecular Mechanisms Underlying PGF2α-induced Hypertrophy of Vascular Smooth Muscle Cells

概要

論文の詳細を見る
The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2α-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2α signaling pathway in three parts: PGF2α binding to its receptor, transactivation of EGF receptor, two independent signaling transduction pathways increasing the expression of NOX1 gene.