Road Transportation Stress Promptly Increases Bovine Peripheral Blood Absolute NK Cell Counts and Cortisol Levels

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Livestock transportation effects on the number of circulating leukocytes have been reported. However, data related specifically to the relation between acute stress levels during transport and leukocyte differentiation, including lymphocyte subsets, are lacking. This study was undertaken to evaluate the distribution of peripheral blood leukocyte differential counts, CD25+ lymphocytes, and NK cells in calves subjected to truck-transportation on different road types. Healthy 6–9-month-old Japanese Black calves were divided into three treatments: 1) those moved around in a mountainous area (Group M); 2) those moved around on flatland (Group F); and 3) those which were not transported (control). Plasma cortisol levels in Group M increased during transport. That increase was significantly higher at the end of transport than in controls (P<0.05); a slight increase was noted in Group F. Total leukocytes and neutrophil/lymphocyte ratios in Group M were elevated with neutrophilia at 2 hr post-transport (P<0.05); the former levels remained higher than those in controls for 4 hr. The numbers of lymphocytes, monocytes, eosinophils, and CD25+ lymphocytes remained unchanged throughout observations. Circulating NK cells in Group M were raised during transport and peaked shortly after transport (P<0.05). Subsequently to these time points, their counts in Group F showed a trend toward elevation. The circulating NK cell counts were positively correlated with plasma cortisol levels during transport (M, r=0.755, P<0.0005; F, r=0.653; P<0.005). These results suggest that circulating NK cells might be more rapidly mobilized than other leukocytes. Therefore, they might reflect acute stress levels in calves during road transportation.
社団法人　日本獣医学会の論文

Road Transportation Stress Promptly Increases Bovine Peripheral Blood Absolute NK Cell Counts and Cortisol Levels

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