無酸素/再酸素化により誘導される白血球と血管内皮細胞の相互作用

概要

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It has long been recognized that the microvasculature is exquisitely sensitive to ischemia/reperfusion (I/R) and that hyperadhesiveness of leukocytes to endothelial cells contributes to I/R-induced tissue injury. The phenomenon of I/R has been implicated in the microvascular and parenchymal cell injury associated with several pathological conditions, including gastric ulcer formation, multiple organ failure, cancer metastasis, and organ transplantation. In an effort to define the mechanisms responsible for reperfusion-induced vascular injury, a number of in vitro models have been developed to simulate the responses of endothelial cells to I/R. Due to its simplicity, many investigators have employed monolayers of cultured endothelial cells exposed to anoxia, followed by reoxygenation (A/R) as a model system to mimic I/R-induced vascular changes in vivo. This review will provide an overview of our current understanding of leukocyte-endothelial cell interactions derived from in vitro studies of endothelial cell monolayers exposed to anoxia/reoxygenation, with specific emphasis on the molecular determinants mediating this inflammatory process and the contribution of reoxygenationinduced oxidative stress to the activation of NF-kB and the expression of endothelial surface adhesion molecules.
日本炎症・再生医学会の論文
2003-01-10