Plasma Adiponectin Levels and Left Ventricular Remodeling in Hypertrophic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Adiponectin, which is an adipose-derived protein with antiatherosclerogenic activities, has been reported to be elevated in patients with heart failure. However, there are no reports on the significance of adiponectin in patients with hypertrophic cardiomyopathy (HCM). The purpose of this study was to elucidate the clinical significance of plasma adiponectin levels in HCM patients.Clinical characteristics, echocardiographic parameters, and levels of plasma B-type natriuretic peptide (BNP) and adiponectin were evaluated in 106 HCM patients. The plasma adiponectin levels were 10.8 ± 6.3 (range, 2.7-37.3) μg/mL. Plasma adiponectin levels were positively related to age and inversely related to body mass index (BMI). Among echocardiographic parameters, % fractional shortening (r = -0.20, P = 0.03) and maximum LV wall thickness (r = -0.23, P = 0.02) were inversely related to plasma adiponectin levels. A significant correlation between plasma adiponectin levels and BNP levels was also observed (r = 0.27, P = 0.005). In multivariate analysis, BMI, % fractional shortening, and plasma BNP levels were independent predictors of plasma adiponectin levels.Plasma adiponectin levels are associated with impaired LV systolic function in HCM patients, but not with the LV outflow gradient. Together with BNP, adiponectin can be a useful biomarker for assessing disease severity in HCM patients.
著者
-
Okawa Makoto
Department of Medicine and Geriatrics, Kochi Medical School
-
Doi Yoshinori
Department of Medicine and Geriatrics, Kochi Medical School
-
Kubo Toru
Department Of Medicine And Geriatrics Kochi Medical School
-
Yamasaki Naohito
Department Of Medicine And Geriatrics Kochi Medical School
-
Matsumura Yoshihisa
Department Of Medicine And Geriatrics Kochi Medical School
-
Nishinaga Masanori
Department Of Geriatric Medicine Kochi Medical School
-
Kitaoka Hiroaki
Department Of Cardiology Kokura Memorial Hospital
-
Doi Yoshinori
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
関連論文
- Impact of Metalloproteinases on Left Ventricular Remodeling and Heart Failure Events in Patients With Hypertrophic Cardiomyopathy
- Plasma Adiponectin Levels and Left Ventricular Remodeling in Hypertrophic Cardiomyopathy
- Clinical Profiles of Hypertrophic Cardiomyopathy With Apical Phenotype : Comparison of Pure-Apical Form and Distal-Dominant Form
- Clinical Impact of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy : Results From Kochi RYOMA Study
- 2 Ventricular Remodeling, Heart Failure, and End-stage HCM(Hypertrophic Cardiomyopathy -New Insights into Clinical Course and Management-,ESC-JCS Joint Symposium (ESC-JCS Joint Symposium) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation
- Impact of Metalloproteinases on Left Ventricular Remodeling and Heart Failure Events in Patients With Hypertrophic Cardiomyopathy
- Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B
- Development of complementary expression patterns of E- and N-cadherin in the mouse liver
- OJ-167 HMG-CoA Reductase Inhibitors Improve the Renal Function in Hypertensive Patients(OJ28,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 1 Clinical Heterogeneity of Hypertrophic Cardiomyopathy(Symposium 10 (SY-10) (M) Update in Cardiomyopathy : Novel Approaches ; Novel Targets,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Association between brachial-ankle pulse wave velocity and 3-year mortality in community-dwelling older adults
- PJ-377 Impact of Coronary Intervention on the Outcome of Octogenarians with Acute Myocardial Infarction : Kochi Acute Myocardial Infarction (KAMI) Study(Acute myocardial infarction, clinical(diagnosis/treatment)(10)(IHD),Poster Session(Japanese),The 72nd
- OJ-095 Abdominal Visceral Fat Thickness Measured by Ultrasonography, but not Waist Circumference, is Predictive of Coronary Artery Disease(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
- PJ-439 Long-term Prognosis of Dilated Cardiomyopathy without Complete Left Ventricular Reverse Remodeling after Beta-blocker Therapy(Cardiomyopathy, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-348 Tissue Characterization of Positive Remodeling Coronary Arterial Plaques by Integrated Backscatter Intravascular Ultrasound(Intravascular endoscopy/Intravascular ultrasound-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Assay for Simultaneous Measurement of Salivary Testosterone and Cortisol in Healthy Men for Utilization in the Diagnosis of Late-onset Hypogonadism in Males
- Single Nucleotide Polymorphism Analysis of the Follicle-stimulating Hormone (FSH) Receptor in Japanese with Male Infertility : Identification of Codon Combination with Heterozygous Variations of the Two Discrete FSH Receptor Gene
- Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy : Comparison with B-type natriuretic peptide
- B-type natriuretic peptide is predictive of hospitalization in community-dwelling elderly without heart diseases
- PJ-637 Clinical Profiles of Hypertrophic Cardiomyopathy with Apical Phenotype : Comparison of Pure-apical Form and Distal-dominant Form(PJ107,Cardiomyopathy/Hypertrophy (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- OE-020 Genetic Screening and Compound Mutations in Patients with Hypertrophic Cardiomyopathy(OE04,Cardiomyopathy/Hypertrophy (Clinical) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-090 Identification of a Novel Disease Gene for Hypertrophic Cardiomyopathy(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- Improvement in prognosis of dilated cardiomyopathy in the elderly over the past 20 years
- Hypertrophic cardiomyopathy with mild left ventricular remodeling : Echocardiographic assessment using left ventricular wall motion score
- PJ-242 Adiponectin is Superior to BNP in Predicting Dilated Phase of Hypertrophic Cardiomyopathy(Cardiomyopathy, basic/clinical(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-083 Can Diastolic Function Assessed by Tissue Doppler Imaging and BNP Level Predict Exercise Capacity in HCM?(Echo/Doppler(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Factors associated with carotid atherosclerosis in community-dwelling oldest elderly aged over 80 years
- Effects of long-term exercise class on prevention of falls in community-dwelling elderly : Kahoku longitudinal aging study
- PJ-563 Nitric Oxide Has Beneficial Effects on Cardiomyocytes by Activation of the Vascular Endothelial Growth Factor(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Synthesis of Helical Polymers with a Pentasilane Core
- PE-335 Assessment of Mitral Annular Velocities Using Tissue Doppler Imaging is Useful in the Prediction of Prognosis in Hypertrophic Cardiomyopathy(Echo/Doppler-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-278 Severe Tricuspid Regurgitation in the Aged : Atrial Remodeling Associated with Long-standing Atrial Fibrillation(Valvular heart disease/Pericarditis/Cardiac tumor-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Is Baker's Cyst a Risk Factor for Pulmonary Embolism?
- PJ-303 Three-year Dependence in Community-dwelling Elderly can be Predicted by Higher BaPWV Plus TNF-α : Kahoku Study(Atherosclerosis, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-225 Morning Systolic Blood Pressure at Home on the 2nd Day is the Best Predictor of Prognosis in the Community-dwelling Elderly(Preventive medicine/Epidemiology/Education-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Multidisciplinary Team Approach for Elderly Patients with Chronic Heart Failure(How to Manage the Very Elderly Patient with Heart Failure, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Quantitative analysis of carotid atherosclerotic lesions and high-sensitivity C-reactive protein in community-dwelling elderly 80 years or older
- Long-Term Prognosis of Dilated Cardiomyopathy Revisited : An Improvement in Survival Over the Past 20 Years
- PJ-201 LV Reverse Remodeling after Beta-blocker Therapy and Long-term Prognosis in Patients with Dilated Cardiomyopathy(Heart failure, clinical-11 (M) PJ34,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
- 7 Non-smoking is Important for "Successful Aging of being Active 85" in Community-dwelling Elderly : Ten-year Longitudinal Study(Tobacco Free Symposium: The Present Condition of Tobacco Control in Japan, the Risk of Smoking to Cardio-and Cerebro-Vascular
- Functional Assessment by Myocardial Performance Index (Tei Index) Correlates With Plasma Brain Natriuretic Peptide Concentration in Patients With Hypertrophic Cardiomyopathy
- OE-296 Right Ventricular Dysfunction Identified by TEI Index Predicts a Poor Prognosis in Patients With Hypertrophic Cardiomyopathy(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English))
- FRS-137 Non-smoking is a significant factor for "successful aging" in community-dwelling elderly over 75 years old : Ten-year longitudinal study.(Gender and Geriatric Medicine and Risk Factors (H) : FRS17)(Featured Research Session (English))
- The Low Serum Lipoprotein (a) Level Is a Predictor of Successful Aging in the Community-Dwelling Elderly over 75 Years Old
- High Value of Systolic Home Blood Pressure Is an Independent Risk Factor for Loosing Independency in Elderly over 75 Yrs.
- Thallium Scintigraphy for the Prognosis of Idiopathic Dilated Cardiomyopathy
- Long-Term Prognosis of Patients With Mildly Dilated Cardiomyopathy
- Aortic plaque in patients with degenerative aortic valvular stenosis
- Long-Term Clinical Course of Hypertrophic Cardiomyopathy in Regional Cohort from Rural Japan
- Natriuretic Peptides and TEI Index in Patients with Hypertrophic Cardiomyopathy
- TEI index in Patients with Hypertrophic Cardiomyopathy : Relation to Left Ventricular Morphology and Extent of Hypertrophy
- PE-218 Twelve-year Regional Experience in the Management of Acute Myocardial Infarction in the Elderly : Kochi Acute Myocardial Infarction (KAMI) Study(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PE38)(Poster Session (English))
- Factors associated with falling in patients with Parkinson's disease and atypical parkinsonism : An assessment using the Tinetti Gait and Balance Scale
- Transperineal microwave needle ablation of the prostate in the canine prostatic hyperplasia model and patients with benign prostatic enlargement
- Evidence-based clinical practice guidelines for bladder cancer (Summary - JUA 2009 Edition)
- Clinical guidelines for nocturia
- PE-072 A Novel Nonsense Mutation in the Cardiac Myosin-binding Protein C Gene and Heterogeneous Clinical Presentation in Hypertrophic Cardiomyopathy(Cardiomyopathy, basic/clinical-3 (M) PE12,Poster Session (English),The 70th Anniversary Annual Scientific
- FRS-054 A Novel Frameshift Mutation in the Cardiac Myosin-binding Protein C Gene and Stroke in a Large Family of Hypertrophic Cardiomyopathy(Frontier of Cardiomyopathy Research-1 (M) FRS11,Featured Research Session,The 70th Anniversary Annual Scientific M
- Mechanism of Exercise Limitation in Nonobstructive Hypertrophic Cardiomyopathy : Significance of TEI (Total Ejection Isovolume) Index
- Echocardiographic Differentiation of End-stage Hypertrophic Cardiomyopathy from Dilated Cardiomyopathy (Echo/Doppler 11 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Morphologic Characteristics in Hypertrophic Cardiomyopathy of the Elderly with Sarcomere Protein Gene Mutations(Cardiomyopathy, Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Prevalence and Prognosis of Patients with Hypertrophic Cardiomyopathy and Left Ventricular Systolic Dysfunction(Cardiomyopathy, Clinical 8 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Long-term Prognosis of Dilated Cardiomyopathy Revisited(Cardiomyopathy, Clinical 8 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-508 Early vs. Late Mortality in Patients with Idiopathic Dilated Cardiomyopathy(Heart Failure, Clinical 13 (M) : PJ85)(Poster Session (Japanese))
- PJ-183 Post-operative Pleural Effusion in Off-pump Surgery Era(Cardiovascular Surgery/CABG 2 (IHD) : PJ31)(Poster Session (Japanese))
- OJ-385 Prognostic Significance of Mid-diastolic Wave in the Mitral Inflow in Patients With Hypertrophic Cardiomyopathy(Echo/Doppler 13 (I) : OJ47)(Oral Presentation (Japanese))
- OJ-333 Treatment with HMG CoA Reductase Inhibitors Reduces the Progression of Aortic Valve Stenosis in the Elderly(Valvular Heart Disease/Pericarditis/Cardiac Tumor 2 (M) : OJ40)(Oral Presentation (Japanese))
- Laparoscopic versus open radical prostatectomy : Urodynamic evaluation of vesicourethral function
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the progression of renal dysfunction in Japanese hypertensive patients
- Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy
- Hypertrophic cardiomyopathy in the elderly
- Low-dose dobutamine stress echocardiography predicts the improvement of left ventricular systolic function and long-term prognosis in patients with idiopathic dilated cardiomyopathy
- Cancer death from non-muscle invasive bladder cancer : Report of the Japanese Urological Association of data from the 1999-2001 registry in Japan
- A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy
- A novel cardiac myosin-binding protein C S297X mutation in hypertrophic cardiomyopathy
- Combined Measurements of Cardiac Troponin I and Brain Natriuretic Peptide Are Useful for Predicting Adverse Outcomes in Hypertrophic Cardiomyopathy
- Heart Failure in the Elderly
- Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy : Report of two initial cases
- Endothelin-1 and Prognosis in Patients with Hypertrophic Cardiomyopathy (Neurohumoral Factors 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Hypertrophic Cardiomyopathy and Heart Failure Dealth in a Regional Cohort(Heart Failure, Clinical 18 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Synthesis and low-temperature dehydrating imidation polymerization of 1,4-dihydro-1,4-diarsininetetracarboxylic acid dianhydride
- Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population : Results from Kochi RYOMA study
- Myocardial Enhancement on Magnetic Resonance Imaging With Gadolinium-Diethylenetriamine Pentaacetic Acid and Improvement of Left Ventricular Function in Patients With Dilated Cardiomyopathy
- De novo detrusor underactivity after laparoscopic radical prostatectomy
- Echocardiographic risk stratification for ischemic stroke in non-rheumatic atrial fibrillation : Importance of aortic plaques detected by transesophageal echocardiography
- Significance of serum osteoprotegerin and receptor activator of nuclear factor κB ligand in Japanese prostate cancer patients with bone metastasis
- Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection
- Turbulent left-to-right shunt flow through the interatrial septum suggesting high left atrial pressure in patients with heart failure with preserved ejection fraction
- Prevalence and Distribution of Sarcomeric Gene Mutations in Japanese Patients With Familial Hypertrophic Cardiomyopathy
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Genetic Screening and Double Mutation in Japanese Patients With Hypertrophic Cardiomyopathy
- Usefulness of High-Sensitive Cardiac Troponin T for Evaluating the Activity of Cardiac Sarcoidosis
- Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence : Report of three initial cases
- Myelodysplastic syndrome treated effectively with testosterone enanthate
- Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia
- Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
- Multiple coronary artery-left ventricle microfistulae
- Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation