Design and Synthesis of C-Ring Lactone- and Lactam-Based Podophyllotoxin Analogues as Anticancer Agents

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概要

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• A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO2) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100 μg/ml) than their cytotoxicity values.

著者

• Singh Pragya

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Faridi Uzma

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Srivastava Suchita

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Kumar Jonnala

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Darokar Mahender

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Luqman Suaib

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Shanker Karuna

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Chanotiya Chandan

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Gupta Atul

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Gupta Madan

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

• Negi Arvind

  Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

関連論文

• Design and Synthesis of C-Ring Lactone- and Lactam-Based Podophyllotoxin Analogues as Anticancer Agents

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