Synthesis and Antiviral Activity of Phthiobuzone Analogues

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概要

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• A series of phthiobuzone analogs, prepared from potassium phthalimide or phthalandione, have been evaluated for their antiviral activities. Among the candidates, compounds 5j and 5k, which contain the substituted 4-halogenated phenyl ring at N-4′,4″ position, show more potent antiviral activity than phthiobuzone against herpes simplex virus 1 (IC50=8.56 and 2.85 μg/ml, respectively) and herpes simplex virus 2 (IC50=1.75 and 4.11 μg/ml, respectively). Compounds 9c and 9d with a propylene linker between the phthalimide and bisthiosemicarbazone moieties display similar antiviral potency against herpes simplex virus 1 (IC50=2.85 and 4.11 μg/ml, respectively).

• 公益社団法人　日本薬学会の論文

著者

• Zhang Pei-cheng

  Key Lab. Of Bioactive Substances And Resources Utilization Of Chinese Herbal Medicine (ministry Of E

• Yang Ya-Jun

  Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministr

• Zhao Jing-Hua

  Beijing Union Pharmaceutical Factory

• Pan Xian-Dao

  Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministr

• Yang Ya-Jun

  Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

• Pan Xian-Dao

  Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

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