Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli

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概要

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• The aryl hydrocarbon receptor (AhR) was originally identified as a ligand-activated transcription factor that is involved in the induction of xenobiotic-metabolizing Cytochrome P4501A1 (CYP1A1). For several decades, AhR has been studied in relation to toxicology and pharmacology. With recent discoveries on novel AhR functions, AhR research has expanded into multiple aspects of physiology, such as reproduction, innate immunity and tumor suppression. In this review, we summarize and discuss recent progress in mechanistic and functional studies on AhR with particular emphasis on physiological processes.(Communicated by Takao SEKIYA, M.J.A.)

• 日本学士院の論文

著者

• Kawajiri Kaname

  Research Institute For Clinical Oncology Saitama Cancer Center

• FUJII-KURIYAMA Yoshiaki

  Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan and Medical Resea

• FUJII-KURIYAMA Yoshiaki

  Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan and Medical Research Institute, Tokyo Medical Dental University

関連論文

• B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor
• Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli
• Regulation of Nucleo-Cytoplasmic Transport of the Aryl Hydrocarbon Receptor
• W1-3 Association between CYP1B1 genetic polymorphism and susceptibility to breast or lung cancer.(Proceedings of the 27th Annual Meeting)

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